Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.123 0.211
biological_process el 1648 0.008 1.0 0.617 0.273
biological_process ka 1648 0.0 1.0 0.119 0.212
biological_process rf 1648 0.0 1.0 0.123 0.211
cellular_component ct 358 0.0 0.952 0.174 0.261
cellular_component el 358 0.009 0.973 0.402 0.259
cellular_component ka 358 0.0 0.978 0.187 0.285
cellular_component rf 358 0.0 0.952 0.174 0.261
disease ct 1456 0.0 1.0 0.042 0.135
disease el 1456 0.0 1.0 0.42 0.299
disease ka 1456 0.0 1.0 0.044 0.146
disease rf 1456 0.0 0.999 0.042 0.135
genetic_interaction ct 1606 0.0 1.0 0.417 0.327
genetic_interaction el 1606 0.0 1.0 0.436 0.32
genetic_interaction ka 1606 0.0 1.0 0.84 0.364
genetic_interaction rf 1606 0.0 1.0 0.424 0.329
molecular_function ct 1275 0.0 0.997 0.262 0.29
molecular_function el 1275 0.001 0.994 0.507 0.264
molecular_function ka 1275 0.0 1.0 0.263 0.294
molecular_function rf 1275 0.0 0.998 0.262 0.291
pathway ct 555 0.001 1.0 0.274 0.342
pathway el 555 0.001 1.0 0.236 0.338
pathway ka 555 0.001 1.0 0.463 0.49
pathway rf 555 0.001 1.0 0.228 0.334
phenotype ct 1391 0.0 0.997 0.072 0.164
phenotype el 1391 0.0 1.0 0.512 0.285
phenotype ka 1391 0.0 1.0 0.069 0.169
phenotype rf 1391 0.0 0.997 0.072 0.164
protein_interaction ct 1657 0.0 1.0 0.07 0.163
protein_interaction el 1657 0.0 0.933 0.065 0.157
protein_interaction ka 1657 0.0 1.0 0.304 0.455
protein_interaction rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 0.992 0.228 0.255
integration_mean_by_presence el 1676 0.0 0.978 0.18 0.174
integration_mean_by_presence ka 1676 0.0 1.0 0.058 0.149
integration_mean_by_presence rf 1676 0.0 0.97 0.058 0.125
mean ct 1676 0.0 0.997 0.186 0.258
mean el 1676 0.0 0.975 0.161 0.169
mean ka 1676 0.0 1.0 0.049 0.143
mean rf 1676 0.0 0.942 0.05 0.117

CDF plots of non integrated kernels

CDF plots of integrated kernels